PubMed · 1977 · 475 citations · 14 references
Morphological EffectsFetal MedicineOrgan DevelopmentEmbryologyFetal Lamb LungTracheobronchitisPulmonary CirculationLung Liquid FlowMorphogenesisLarynxRespiration (Physiology)Embryonic DevelopmentCell BiologyFetal Lung DevelopmentDevelopmental BiologyChronic Tracheal LigationPhysiologyPulmonary PhysiologyLung MechanicsFetal ComplicationMedicineNeonatal Pulmonary Physiology
Lung liquid flow has been examined at the cellular level to understand its role in fetal lung development. Continuous in utero tracheal ligation and drainage for 21–28 days cause fetal lamb lung malformations, with ligated lungs enlarged, showing increased alveolar wall thinning and reduced type II cells, while drained lungs are smaller, exhibit inhibited thinning and increased type II cells, underscoring the critical role of fetal lung liquid in pulmonary development.
The relationship between lung liquid flow and fetal lung development has been studied at the cellular level using ultrastructural techniques. Continuous in utero tracheal ligation and drainage (over a period of 21-28 days) both result in malformations of the developing fetal lamb lung. Ligated lungs are larger, and drained lungs are smaller, than normal lungs at a similar gestational age. These changes are not merely due to altered lung liquid volume, but actual tissue growth thas been affected. Future alveolar wall thinning is enhanced in ligated lungs and inhibited in drained lungs, whilst the presence of differentiated alveolar type II cells (probably related to surfactant production) is decreased in ligated lungs and markedly enhanced in drained lungs. These results indicate the importance of fetal lung liquid in the regulation of pulmonary development in the fetus.
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Morphologic development of fetal rabbit lung and its acceleration with cortisol.
Yutaka Kikkawa, Makoto Kaibara, Etsuro K. Motoyama et al. · PubMed · 1971 · 219 citations · Full text