FORMULATION AND OPTIMIZATION OF PROLONGED RELEASE NASAL IN SITU GEL FOR TREATMENT OF MIGRAINE

Abstract

Article history The nasal route has been found to be useful in targeting drugs to the central nervous system. The nasal mucosa offers numerous benefits as a target tissue for drug delivery. Systemic delivery of drug via nasal route is associated with the several positive factors such as relatively large surface area available for absorption and avoidance of first pass effects. The poor bioavailability and therapeutic response exhibited by the conventional nasal sprays and drops due to rapid nasal elimination of the drug may be overcome by the use of in situ gelling systems that are instilled as drops into the nasal cavity and undergo a sol-to-gel transition. The purpose of this research was to develop and optimize nasal in situ gel of Zolmitriptan by using Cold method. The effect of two independent process variables like combination of thermoreversible polymers and bioadhesive polymer on gelation time, gelation temperature and drug release of nasal in situ gel containing Zolmitriptan was optimized using 3 2 factorial design. The observed responses were coincided well with the predicted values, given by the optimization technique. The optimized the optimized nasal in situ gel shows gelation time 59.73±0.02, gelation temperature 31.93±0.11, and drug release 65.2±0.23 after 8 hrs. Compatibility studies of drug and excipients were carried out using FTIR. The developed formulations were characterized for gelation time, gelation temperature, bioadhesive strength, gel strength, viscosity, in-vitro drug release, ex -vivo drug release and in-vitro, ex -vivo drug release kinetics.