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Development and validation of a bioanalytical method for the simultaneous determination of heroin, its main metabolites, naloxone and naltrexone by LC–MS/MS in human plasma samples: Application to a clinical trial of oral administration of a heroin/naloxone formulation

Pharmacodynamic ModelingDrug PurityBioanalysisDrug TestDrug MonitoringAnalytical ChemistryHeroinClinical ChemistryChromatographyHealth SciencesTherapeutic Drug MonitoringPharmacologyBioanalytical MethodHeroin/naloxone FormulationForensic ToxicologyDrug TestingMass SpectrometryMedicineHuman Plasma SamplesPharmacokineticsAnesthesiologyDrug Analysis