Organic Letters · 2015 · 76 citations · 65 references
Natural SciencesChemistryOrganic ChemistryCoordination ChemistryCross-coupling ReactionsHeterocycle SynthesisMetal CatalysisMetal-ligand BondingArylation ReactionsCopper-catalyzed CouplingFunctional Group ToleranceMetal-aryl BondingStereoselective Cross-couplingSubstrate ScopeSubstrate Scope ExpansionTransition-metal-catalyzed Functionalization
A copper/silver-mediated arylation of (hetero)aryl C-H bonds with 2-thiophenecarboxylic acids has been achieved. The protocol features a broad substrate scope and high functional group tolerance. Preliminary mechanistic studies indicate that a cascade protodecarboxylation/dehydrogenative coupling process is likely involved.
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