Copper-/Silver-Mediated Arylation of C(sp²)–H Bonds with 2-Thiophenecarboxylic Acids

Abstract

A copper/silver-mediated arylation of (hetero)aryl C-H bonds with 2-thiophenecarboxylic acids has been achieved. The protocol features a broad substrate scope and high functional group tolerance. Preliminary mechanistic studies indicate that a cascade protodecarboxylation/dehydrogenative coupling process is likely involved.