A QUANTITATIVE EVALUATION OF THE CONTRIBUTION OF NITROGEN MUSTARD TO THE THERAPEUTIC MANAGEMENT OF HODGKIN'S DISEASE

Abstract

Article1 December 1951A QUANTITATIVE EVALUATION OF THE CONTRIBUTION OF NITROGEN MUSTARD TO THE THERAPEUTIC MANAGEMENT OF HODGKIN'S DISEASEALFRED GELLHORN, M.D., VINCENT P. COLLINS, M.D.ALFRED GELLHORN, M.D.Search for more papers by this author, VINCENT P. COLLINS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-6-1250 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe nitrogen mustard, methyl bis (beta chloroethyl) amine (HN2), was introduced as a chemotherapeutic agent in the treatment of malignant disease in 1943 by Goodman et al.1Since that time there have been over 50 reports in the American literature describing the immediate effects of nitrogen mustard on a variety of neoplastic processes. Although there has been excellent agreement on the qualitative responses observed in the various clinics, there is but one report which assesses quantitatively the contribution of HN2in the medical management of certain malignant diseases.2Since HN2is now commercially available to the medical profession under the...Bibliography1. GoodmanWintrobeDameshekGoodmanGilmanMcLennan LSMMWMJAZMT: Nitrogen mustard therapy. Use of methyl-bis-(beta-chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders, J. A. M. A. 132: 126, 1946. CrossrefMedlineGoogle Scholar2. SpurrSmithBlockJacobson CLTLMLO: The role of nitrogen mustard therapy in the treatment of lymphomas and leukemias, Am. J. Med. 8: 710, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication October 18, 1950.From the Departments of Medicine and Radiology, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York.This work was aided by a grant from the American Cancer Society.†Merck and Co., Rahway, N. J. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe early history of the biological alkylating agents, 1918–1968Survival of patients with Hodgkin's diseaseDie LymphogranulomatoseLong-term remission in hodgkin's disease after nitrogen mustard therapy.Report of a CaseMechlorethamineLong survival in Hodgkin's diseaseClinical Management of Hodgkin’s DiseaseVinblastine VS. nitrogen mustard therapy of Hodgkin's diseaseThe Treatment of Lymphomas with Vincaleukoblastine and MethylhydrazineTHE MANAGEMENT OF THE DISEASERadiation response of Hodgkin's disease recurrent after chemotherapyThe management of Hodgkin's diseaseHodgkin's Disease — Prognosis, Treatment and Etiologic and Immunologic ConsiderationsManagement of Reticuloendothelial MalignanciesSUMMARY OF RESULTS OBTAINED WITH NITROGEN MUSTARD IN THE TREATMENT OF NEOPLASTIC DISEASECytologie und Klinik der LymphogranulomatoseMethods for analyzing survival data, illustrated by Hodgkin's diseaseDie bösartigen Geschwülste und geschwulstartigen Erkrankungen des Blut- und LymphgewebesTherapy of the malignant lymphomasAdvances in Chemotherapy of Cancer in ManManagement of the patient with Hodgkin's diseaseHODGKIN'S DISEASE: AN ANALYSIS OF FREQUENCY, DISTRIBUTION AND MORTALITY AT THE UNIVERSITY OF CALIFORNIA HOSPITAL, 1914-1951*†M. B. SHIMKIN, M.D., F.A.C.P., K. C. OPPERMANN, B.S., W. L. BOSTICK, M.D., B. V. A. LOW-BEER, M.D., F.A.C.R.CHEMOTHERAPY OF LEUKEMIA, HODGKIN'S DISEASE AND RELATED DISORDERS*M. M. WINTROBE, F.A.C.P., G. E. CARTWRIGHT, PHAEDON FESSAS, ARTHUR HAUT, S. J. ALTMANClinical studies on anticancer agents from 1949 to 1951Recent Developments in Laboratory and Clinical Cancer ChemotherapyChemotherapy of Leukemia and Allied DisordersChildhood cancer (tumors, leukemia, andHodgkin's disease) 1 December 1951Volume 35, Issue 6Page: 1250-1259KeywordsCancer chemotherapyCancer treatmentChemotherapeutic agentsDiagnostic radiologyHodgkin lymphomaHospital medicineQualitative studiesSurgeons ePublished: 1 December 2008 Issue Published: 1 December 1951 PDF downloadLoading ...