PubMed · 2013 · 11 citations · 0 references
MedicineGynecologyOncologyGynecologic OncologySurgical OncologyTumor ProgressionCancer BiomarkersCancer Early DetectionCancer StagingEarly Cancer DetectionOvarian CancerRecurrence MonitoringIncremental Diagnostic ValueLead TimeOvarian Cancer Early DetectionOvarian Cancer Prognostic BiomarkersOvarian Cancer RecurrencePositive Predictive ValuePrognostic Factors AnalysisRecurrent Ovarian Cancer
PURPOSE: The aim of this study was to establish the guidelines for detecting early recurrences of advanced epithelial ovarian cancer by use of the CA-125 level. MATERIALS AND METHODS: Eighty-five of the patients who met the inclusion criteria were enrolled in this study. The authors examined 25 incremental changes of CA125 from one to 25 IU/ml, and compared the CA-125 value with other prognostic factors. Increases in the CA-125 level from the nadir level were expressed as CA-125- increments. RESULTS: Among the 25 increments, a CA-125-8 (eight IU/ml) was selected as the predictor that was the most efficient and time-effective. CA-125-8 had a sensitivity of 91.5%, a specificity of 84.6%, a positive predictive value of 93.1%, a negative predictive value of 81.5%, an efficiency of 89.4%. and a median lead-time of 68.5 days (p <0.0001). CONCLUSION: The authors suggest the incremented CA-125-8 as a predictor of recurrent advanced ovarian cancer.