Maleic acid as inhibitor of enzyme reactions induced by SH-compounds

Abstract

IT has been shown recently [Morgan & Friedmann, 1938] that maleic acid and SH-compounds interact with the formation of well defined, stable addition compounds. We have applied this reaction to the study of some enzyme reactions which are held to be induced by SH-compounds. We have found, in every case examined, that maleic acid inhibits enzyme reactions of this kind or under other conditions decreases their speed.