Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

B N Ames, Richard Cathcart, Elizabeth Schwiers et al. · Proceedings of the National Academy of Sciences · 1981 · 2.9K citations · Full text

Life Sciences, Biochemistry, Physiology +17

Molecular identification of a renal urate–anion exchanger that regulates blood urate levels

Atsushi Enomoto, Hiroaki Kimura, Arthit Chairoungdua et al. · Nature · 2002 · 1.5K citations

Life Sciences, Molecular Biology, Physiology +14

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

Owen M. Woodward, Anna Köttgen, Josef Coresh et al. · Proceedings of the National Academy of Sciences · 2009 · 694 citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

Decreased extra-renal urate excretion is a common cause of hyperuricemia

Kimiyoshi Ichida, Hirotaka Matsuo, Tappei Takada et al. · Nature Communications · 2012 · 691 citations · Full text

Medicine, Nephrology, Physiology +11

Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments

Emma McConnell, Abdul W. Basit, Sudaxshina Murdan · Journal of Pharmacy and Pharmacology · 2007 · 646 citations

Pharmacy, Pharmaceutics, Pharmacology +16