Concepedia

Nelfinavir Induces Adipocyte Insulin Resistance through the Induction of Oxidative Stress: Differential Protective Effect of Antioxidant Agents

Ronit Ben-Romano, Assaf Rudich, Sharon Etzion, R. Potashnik, Ella Kagan, Uri Greenbaum, Nava Bashan

Antiviral Therapy · 2006 · 53 citations · 41 references

DOIFull text

Open access

Abstract

Induction of oxidative stress plays a role in adipocyte insulin resistance and apoptosis induced by NFV through a radical-dependent but thiol-independent mechanism(s). The results may suggest a new mechanism for the adverse effects of NFV on fat cells, and offer potential new intervention approaches.

References

41

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