Ubiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor Immunity

Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen.

K Y Lin, Frank Guarnieri, Kevin F. Staveley-O’Carroll et al. · PubMed · 1996 · 1K citations

Medicine, Immunology, Oncology +17

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

Scott G. Hansen, Julia C. Ford, Matthew S. Lewis et al. · Nature · 2011 · 993 citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +16

Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 Deficiency

Dusan Bogunovic, Minji Byun, Larissa A. Durfee et al. · Science · 2012 · 566 citations · Full text

Life Sciences, Immunology, Infectious Diseases +17

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

Xianqin Zhang, Dusan Bogunovic, Béatrice Payelle‐Brogard et al. · Nature · 2014 · 566 citations · Full text

Life Sciences, Immunology, Molecular Genetics +10

The interferon-inducible 15-kDa ubiquitin homolog conjugates to intracellular proteins.

Keith R. Loeb, Arthur L. Haas · Journal of Biological Chemistry · 1992 · 438 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12