Mutation analysis of APC gene in gastric cancer with microsatellite instability

Genetic Alterations during Colorectal-Tumor Development

Bert Vogelstein, Eric R. Fearon, Stanley R. Hamilton et al. · New England Journal of Medicine · 1988 · 6.7K citations

Tumor Biology, Somatic Variant, Tumor Heterogeneity +13

Identification and characterization of the familial adenomatous polyposis coli gene

Joanna Groden, Andrew Thliveris, Wade S. Samowitz et al. · Cell · 1991 · 2.8K citations

Molecular Epidemiology, Genetic Disorder, Medicine +10

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

Yurij Ionov, Miguel A. Peinado, Sergei Malkhosyan et al. · Nature · 1993 · 2.7K citations

Somatic Variant, Tumor Heterogeneity, Ubiquitous Somatic Mutations +6

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

Christian Bronner, Sean M. Baker, Paul T. Morrison et al. · Nature · 1994 · 2.1K citations

Genome Instability, Somatic Variant, Genetics +5

Genetic instability in colorectal cancers

Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein · Nature · 1997 · 2K citations

Genetic Instability, Medicine, Colorectal Cancer +5