Concepedia

Ignoring Pharmacokinetics May Lead to Isoboles Misinterpretation: Illustration with the Norfloxacin-Theophylline Convulsant Interaction in Rats

Miren Cadart, Sandrine Marchand, Claudine Pariat, S. Bouquet, William Couet

Pharmaceutical Research · 2002 · 36 citations · 6 references

DOI

Concepts

References

6

Kinetics of drug action in disease states. I. Effect of infusion rate on phenobarbital concentrations in serum, brain and cerebrospinal fluid of normal rats at onset of loss of righting reflex.

Meindert Danhof, Gerhard Levy · Journal of Pharmacology and Experimental Therapeutics · 1984 · 109 citations

, , +14

Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats.

Iqbal Ramzan, Gerhard Levy · Journal of Pharmacology and Experimental Therapeutics · 1986 · 65 citations

, , +13

Pharmacokinetic-Pharmacodynamic Contributions to the Convulsant Activity of Fluoroquinolones in Rats

Annie Delon, S. Bouquet, François Huguet et al. · Antimicrobial Agents and Chemotherapy · 1999 · 32 citations · Full text

, , +11

Pharmacokinetic-Pharmacodynamic Contributions to the Convulsant Activity of Pefloxacin and Norfloxacin in Rats

Annie Delon, François Huguet, Philippe Courtois et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 29 citations

, , +13

Development of a New Quantitative Approach for the Isobolographic Assessment of the Convulsant Interaction Between Pefloxacin and Theophylline in Rats

Laurence M. Levasseur, Annie Delon, William R. Greco et al. · Pharmaceutical Research · 1998 · 12 citations

, , +8