PubMed · 1986 · 15 citations · 14 references
MedicineDermatologyOncologyCarcinogenesisCutaneous OncologyNeoplasiaCarcinogenic MechanismsChemical CarcinogenesisMalignant NeoplasmsSkin TumorsSquamous Cell CarcinomaTumor PromotionCarcinogen FormationChemical Carcinogen ExposureChemical Carcinogenesis PromotionMechanisms Of CarcinogenicityMechanisms Of Chemical CarcinogenesisSkin CarcinogenesisSkin Tumor PromotionTwo-stage Carcinogenesis
In two separate experiments, 2.0 mg of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) was applied to the back of female CD-1 mice twice weekly for 5 weeks followed by application of 2.5 micrograms of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) twice weekly for 47 weeks. Skin squamous cell papillomas and carcinomas developed in 6 of 20 mice (30%) in Experiment 1 and in 3 of 19 mice (16%) in Experiment 2. In contrast, application of 2.0 mg of Trp-P-2 twice weekly for 52 weeks did not produce any skin tumors. These data suggest that Trp-P-2 acts primarily as an initiator, not as a complete carcinogen, for mouse skin.
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