American Journal of Psychiatry · 1984 · 281 citations · 26 references
Social SciencesNeurologyNeuroscienceChild PsychiatryNeuropsychiatryNeuropsychologyBrain ImagingNeurodevelopmental AssessmentNeuropsychological AssessmentObsessive-compulsive DisordersPediatric Neurologic DisordersPediatric NeuropsychologyBrain Ventricular AssessmentFrontal Lobe LesionsNeuropsychological FunctioningNeuropsychological ImpairmentNeuropsychological Test BatteriesObsessive-compulsive Disorder In ChildrenSpatial Memory DeficitsVisual Perceptual Deficits
The authors administered CAT scans and neuropsychological tests to 16 adolescents with obsessive-compulsive disorder (mean age +/- SD = 13.7 +/- 1.6 years) and 16 matched controls. The patients had a mean ventricular-brain ratio (VBR) significantly higher than the controls' and showed spatial-perceptual deficits similar to those found in patients with frontal lobe lesions. Memory, reaction time, and decision time did not differ significantly from controls'. Neurodevelopmental examination of seven patients yielded a high frequency of age-inappropriate synkinesias and left hemibody signs. These results suggest CNS dysfunctioning in children with obsessive-compulsive disorder, with possible right cerebral involvement. However, the patients' neuropsychological test deficits and VBRs were not correlated.
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Functional Asymmetry of the Brain in Dichotic Listening
Doreen Kimura · Cortex · 1967 · 1.6K citations