PHOSPHATASE CONTENT OF BLOOD SERUM AND TISSUES IN THE RAT FOLLOWING ADMINISTRATION OF VITAMINS D AND A

Abstract

Baumgartner, King, and Page (l), on feeding irradiated ergosterol to rabbits, found that the total phosphatase content of bones was diminished.Page and Reside (2) later reported little or no change of phosphatase content after feeding ergosterol.It has been suggested that they were working with an inactive preparation.Kinard and Chanutin (3) found that irradiated ergosterol caused a rise in phosphatase activity in whole rats up to 60 days, but no change in adult animals despite the disturbance in calcium metabolism.Taylor, Weld, Branion, and Kay (4) found that phosphatase in plasma, bone, and kidney of the rat was reduced after irradiated ergosterol.Hansen (5) reported the reduction of phosphatase in serum in four cases of osteogenesis imperfecta following enormous doses of 10,000 X .EXPERIMENTAL