Concepedia

Inhibition of P-Glycoprotein: Rapid Assessment of Its Implication in Blood-Brain Barrier Integrity and Drug Transport to the Brain by an In Vitro Model of the Blood-Brain Barrier

Laurence Fénart, Valeric Buée‐Scherrer, Laurence Descamps, Christian Duhem, Marie‐Gwenaelle Poullain, Roméo Cecchelli, Marie-Pierre Dehouck

Pharmaceutical Research · 1998 · 77 citations · 26 references

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Concepts

References

26

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

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Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

Victor A. Levin · Journal of Medicinal Chemistry · 1980 · 814 citations

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Human P-glycoprotein transports cyclosporin A and FK506.

Takashi Saeki, Kazumitsu Ueda, Yusuke Tanigawara et al. · Journal of Biological Chemistry · 1993 · 685 citations · Full text

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A New Function for the LDL Receptor: Transcytosis of LDL across the Blood–Brain Barrier

Bénédicte Dehouck, Laurence Fénart, Marie‐Pierre Dehouck et al. · The Journal of Cell Biology · 1997 · 576 citations · Full text

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An Easier, Reproducible, and Mass‐Production Method to Study the Blood–Brain Barrier In Vitro

Marie‐Pierre Dehouck, Stéphane Méresse, Pierre Delorme et al. · Journal of Neurochemistry · 1990 · 543 citations

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