Synthesis and evaluation of pyrrolotriazine based molecules as PI3 kinase inhibitors

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Zachary A. Knight, Beatriz González, Morri E. Feldman et al. · Cell · 2006 · 1.1K citations · Full text

Molecular Pharmacology, Metabolic Syndrome, Signal Transduction +14

Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer

Daniel P. Sutherlin, Linda Bao, Megan Berry et al. · Journal of Medicinal Chemistry · 2011 · 212 citations · Full text

Translational Pharmacology, Pre-clinical Pharmacology, Molecular Pharmacology +20

The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3-Kinase α

Timothy P. Heffron, Laurent Salphati, Bruno Alicke et al. · Journal of Medicinal Chemistry · 2012 · 52 citations · Full text

Pi3k Inhibitors, Pharmacotherapy, High-grade Gliomas +24

PI3K Inhibitors for Cancer Therapy: What has been Achieved So Far?

Peng Wu, Tao Liu, Yongzhou Hu · Current Medicinal Chemistry · 2009 · 41 citations

Cancer Therapy, Pi3k Inhibitors, Chemoprevention Strategy +20