A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways.

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

Donald B. Smith, Kevin S. Johnson · Gene · 1988 · 6K citations

Protein Expression, Biochemistry, Single-step Purification +10

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

Anne J. Ridley, Alan Hall · Cell · 1992 · 4.5K citations

Mechanobiology, Focal Adhesions, Actin Stress Fibers +14

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

Anne J. Ridley, Hugh F. Paterson, Caroline L. Johnston et al. · Cell · 1992 · 3.6K citations

Signal Transduction, Developmental Biology, G Protein-coupled Receptor +8

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

László Buday, Julian Downward · Cell · 1993 · 1.1K citations

Exchange Factor, Epidermal Growth Factor, Signal Transduction +8

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

Sally J. Leevers, Hugh F. Paterson, Christopher J. Marshall · Nature · 1994 · 1K citations

Signal Transduction, Plasma Membrane, Medicine +7