In Vivo Models of Platelet Function and Thrombosis: Study of Real-Time Thrombus Formation

Abstract

Our understanding of hemorrhagic and thrombotic diseases has expanded with use of models aimed at studying the vasculature using a variety of different animals. Unlike in vitro experiments, these animal models enable the study of the broad continuum of biological consequences induced by alterations made to a single variable. This chapter briefly reviews animal models used in the study of thrombosis research, focusing primarily on the use of intravital fluorescence microscopy.