In vitro and in vivo antiproliferative effects of simvastatin, an HMG-CoA reductase inhibitor, on human glioma cells

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Tim R. Mosmann · Journal of Immunological Methods · 1983 · 55.6K citations

Life Sciences, Cell Biology, Apoptosis +14

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

Alfred W. Alberts, J Chen, G. W. Kuron et al. · Proceedings of the National Academy of Sciences · 1980 · 1.6K citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

p21ras is modified by a farnesyl isoprenoid.

Patrick J. Casey, Patricia A. Solski, Channing J. Der et al. · Proceedings of the National Academy of Sciences · 1989 · 855 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

The p21 ras C-terminus is required for transformation and membrane association

Berthe M. Willumsen, Annette Christensen, N L Hubbert et al. · Nature · 1984 · 604 citations

Life Sciences, Cell Biology, Molecular Biology +10

Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

Esther H. Chang, Mark E. Furth, Edward M. Scolnick et al. · Nature · 1982 · 595 citations

Medicine, Molecular Biology, Oncology +17