The Legacy of cell fusion

Abstract

1. Heterokaryons reveal that differentiation requires continuous regulation 2. The instability of differentiation in hepatomas 3. Nuclear protein sorting in heterokaryons and homokaryons 4. Some insights into the replication of damaged DNA in mammalian cells 5. The role of the nucleolus in the transfer of information from nucleus to cytoplasm 6. Transcription by immobile RNA polymerases 7. Lateral mobility of membrane proteins - a journey from heterokaryons to laser tweezers 8. Intracellular transport of secretory proteins within intact transient heterokaryons and homokaryons 9. Radiation hybrid mapping: an idea whose time has finally arrived 10. The cloning of tumour suppressor genes 11. The road to monoclonal antibodies 12. The genetic analysis of human cancer 13. Genes in control of cell proliferation and tumorigenesis in Drosophila 14. Genetics and molecular biology of tumour formation in Xiphophorus 15. Loss of function mutations in human cancer 16. Cancer suppression by the retinoblastoma gene 17. The p53 pathway: past and future 18. Somatic cell genetics and the search for colon cancer genes 19. Roles of the myc gene in cell proliferation and differentiation, as deduced from its role in tumorigenesis 20. Genes that suppress the action of mutated ras genes 21. Unfinished business