The assimilation of amino-acids by bacteria. 14. Nucleic acid and protein synthesis in <i>Staphylococcus aureus</i>

Abstract

From Table 2 it will also be seen that the diabetogenic dose of alloxan in normal animals, as found in this laboratory, ranges between 130 and 140 mg./kg. and the lethal dose is observed to be in the neighbourhood of 225 mg./kg. It is interesting to note that the diabetogenic and lethal doses of alloxan in acetoacetate-treated animals, having blood GSH in the neighbourhood of 3 mg./100 ml., are only 75 and 100 mg./kg., respectively. Continued injection of acetoacetate for a few weeks has thus a definite effect in making the animals sus- ceptible to alloxan.