Drug points: Pravastatin: interaction with oral anticoagulant?

Abstract

Pravastatin is a hydrophilic competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme A, the enzyme responsible for the rate limiting step of endogenous cholesterol synthesis. Interaction studies with oral anticoagulants have shown no change in prothrombin time or in the pharmacokinetic variables of pravastatin.1 On the other hand, when lovastatin2 or simvastatin3 and coumarin are administered concomitantly, prothrombin time may be increased in …