Triptolide prevents and attenuates neuropathic pain via inhibiting central immune response.

Ethical guidelines for investigations of experimental pain in conscious animals

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Pain Therapy, Pain Syndrome, Behavioral Sciences +12

Interactions between the immune and nervous systems in pain

Ke Ren, Ronald Dubner · Nature Medicine · 2010 · 797 citations

Inflammation, Pain Syndrome, Health Sciences +9

ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model

Zhi‐Ye Zhuang, Peter Gerner, Clifford J. Woolf et al. · Pain · 2005 · 766 citations

Pain Medicine, Erk Kinase, Neuropathic Pain +18

A Peptide c-Jun N-Terminal Kinase (JNK) Inhibitor Blocks Mechanical Allodynia after Spinal Nerve Ligation: Respective Roles of JNK Activation in Primary Sensory Neurons and Spinal Astrocytes for Neuropathic Pain Development and Maintenance

Zhi‐Ye Zhuang, Yeong‐Ray Wen, De-Ren Zhang et al. · Journal of Neuroscience · 2006 · 514 citations · Full text

Jnk Substrate, Pain Medicine, Neuropathic Pain +19

The cytokine network of Wallerian degeneration: tumor necrosis factor-alpha, interleukin-1alpha, and interleukin-1beta.

Shlomit Shamash, Fanny Reichert, Shlomo Rotshenker · PubMed · 2002 · 483 citations · Full text

Immunology, Cell Death, Pathology +21