Organic & Biomolecular Chemistry · 2025 · 10 citations · 62 references
Natural SciencesChemistryMedicinal ChemistryDrug DiscoveryGreen ChemistryOrganic ChemistryCross-coupling ReactionsHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsPhotochemical SynthesisPhotochemistryElectron TransferEnergy TransferGreen Heterocycle SynthesisGreen SynthesisHydrogen Atom TransferNitrogen HeterocyclesPhotocyclization ReactionsRadical Cyclization
mechanisms such as single-electron transfer (SET), energy transfer (EnT), or hydrogen atom transfer (HAT), minimizing intermediate isolation and purification steps. This review highlights recent advances in visible-light-induced domino reactions for the synthesis of nitrogen-containing heterocycles. It focuses on key strategies, including nitrogen-centered radical-mediated C-N bond formation and carbon-centered radical-initiated cyclization, discussing their mechanisms, current limitations, and future prospects to provide insights for advancing green synthesis and pharmaceutical science.
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Monroe E. Wall, Mansukh C. Wani, Clarence Cook et al. · Journal of the American Chemical Society · 1966 · 2.2K citations
When Light Meets Nitrogen-Centered Radicals: From Reagents to Catalysts
Xiaoye Yu, Quanqing Zhao, Jun Chen et al. · Accounts of Chemical Research · 2020 · 499 citations