Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression

Mingxu Xie, Kai Yuan, Yongxin Zhang, Yating Zhang, Ruyi Zhang, Wenchao Wei, Lanping Jiang, Tianhui Li, Yanqiang Ding, Luyao Wang,

Cancer Cell · 2025 · 52 citations · 40 references

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Abstract

humanized mice and autologous patient-derived CRC organoids-CTLs co-culture system. To summarize, C. butyricum is a promising adjuvant to augment ICB therapy.

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