British Association for Sexual Health and HIV (BASHH) UK national guideline for the use of doxycycline post-exposure prophylaxis (DoxyPEP) for the prevention of syphilis, 2025

Abstract

This guideline provides evidence-based recommendations for the use of doxycycline post exposure prophylaxis (doxyPEP) for the prevention of syphilis. DoxyPEP should be part of a comprehensive approach to the prevention of STIs, along with condom use, appropriate HIV prevention interventions, vaccination, STI testing, treatment and management, and appropriate risk reduction advice and psychological interventions if indicated.