Gut Microbiota Modulation through <i>Akkermansia</i> spp <i>.</i> Supplementation Increases CAR T-cell Potency

Abstract

B-cell lymphoma patients treated with CAR T cells harbor major gut microbiota perturbations and related metabolism that restrain CAR T-cell therapy. Reprogramming the gut microbiota ecosystem by oral A. massiliensis supplementation induces CAR T-cell niching and Tc1 differentiation in the bone marrow, promoting tumor control in an AhR-dependent manner.