Concepedia

Omitting Regional Nodal Irradiation after Response to Neoadjuvant Chemotherapy

Eleftherios P. Mamounas, Hanna Bandos, Julia White, Thomas B. Julian, Atif J. Khan, Simona F. Shaitelman, Mylin A. Torres, Frank A. Vicini, Patricia A. Ganz, Susan A. McCloskey,

New England Journal of Medicine · 2025 · 44 citations · 24 references

DOIFull text

Open access

Abstract

The addition of adjuvant regional nodal irradiation did not decrease the risk of invasive breast cancer recurrence or death from breast cancer in patients who had negative axillary nodes after neoadjuvant chemotherapy. (Funded by the National Institutes of Health; NSABP B-51-Radiation Therapy Oncology Group 1304 ClinicalTrials.gov number, NCT01872975.).

References

24

Postoperative Radiotherapy in High-Risk Premenopausal Women with Breast Cancer Who Receive Adjuvant Chemotherapy

Marie Overgaard, Per Syrak Hansen, Jens Overgaard et al. · New England Journal of Medicine · 1997 · 2.6K citations

Effect of preoperative chemotherapy on local-regional disease in women with operable breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-18.

Bernard Fisher, A Brown, E.P. Mamounas et al. · Journal of Clinical Oncology · 1997 · 1.8K citations

Adjuvant Radiotherapy and Chemotherapy in Node-Positive Premenopausal Women with Breast Cancer

Joseph Ragaz, Stewart M. Jackson, Nhu Le et al. · New England Journal of Medicine · 1997 · 1.8K citations · Full text

Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial

Marie Overgaard, Maj‐Britt Jensen, Jens Overgaard et al. · The Lancet · 1999 · 1.6K citations

, , +8

Sentinel Lymph Node Surgery After Neoadjuvant Chemotherapy in Patients With Node-Positive Breast Cancer

Judy C. Boughey · JAMA · 2013 · 1.5K citations · Full text