Concepedia

Highly conserved brain vascular receptor ALPL mediates transport of engineered AAV vectors across the blood-brain barrier

Tyler C. Moyer, Brett Hoffman, Weitong Chen, Ishan Shah, Xiao‐Qin Ren, Tatiana M. Knox, Jiachen Liu, Wei Wang, Jiangyu Li, Hamza Khalid,

Molecular Therapy · 2025 · 32 citations · 44 references

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44

Highly accurate protein structure prediction with AlphaFold

John Jumper, Alexander Pritzel, Tim Green et al. · Nature · 2021 · 45.2K citations · Full text

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ColabFold: making protein folding accessible to all

Milot Mirdita, Konstantin Schütze, Yoshitaka Moriwaki et al. · Nature Methods · 2022 · 9.7K citations · Full text

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Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy

Jerry R. Mendell, Samiah Al-Zaidy, Richard Shell et al. · New England Journal of Medicine · 2017 · 2.3K citations · Full text

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Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

Ken Y. Chan, Min Jee Jang, Bryan B. Yoo et al. · Nature Neuroscience · 2017 · 1.7K citations

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Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

Benjamin E. Deverman, Piers L. Pravdo, Bryan P. Simpson et al. · Nature Biotechnology · 2016 · 1.1K citations · Full text

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