Concepedia

Natural small molecule thymoquinone increases the chemosensitivity of glioblastoma to temozolomide through inhibiting Wnt/β-catenin signaling pathway to downregulate MGMT expression: In vitro and in vivo validation

Peiying Bai, Peng Wang, Ting Ren, Qing Tang, Ziao Lin, Na Zhang, Lijiao Zhao, Rugang Zhong, Guohui Sun

Biochemical Pharmacology · 2025 · 10 citations · 29 references

DOI

Concepts

References

29

<i>MGMT</i> Gene Silencing and Benefit from Temozolomide in Glioblastoma

Monika E. Hegi, Annie‐Claire Diserens, Thierry Gorlia et al. · New England Journal of Medicine · 2005 · 7.3K citations · Full text

, , +17

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

D. Williams Parsons, Siân Jones, Xiaosong Zhang et al. · Science · 2008 · 5.8K citations · Full text

, , +16

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

Osamu Tetsu, Frank McCormick · Nature · 1999 · 3.6K citations

, , +14

The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

Gideon Steinbach, Patrick M. Lynch, Robin Phillips et al. · New England Journal of Medicine · 2000 · 2.5K citations · Full text

, , +13

Characterization of the Cellular Reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): Subcellular Localization, Substrate Dependence, and Involvement of Mitochondrial Electron Transport in MTT Reduction

Michael V. Berridge, An S. Tan · Archives of Biochemistry and Biophysics · 1993 · 1.4K citations

, , +15