Concepedia

Pharmacologically targeting fatty acid synthase-mediated de novo lipogenesis alleviates osteolytic bone loss by directly inhibiting osteoclastogenesis through suppression of STAT3 palmitoylation and ROS signaling

Chunmei Xiu, Lei Zhang, Chenxi Zhang, Xi Luo, Ziyi Zhang, Kaizhong Ji, Zhiyuan Chen, Guangxu He, Jianquan Chen

Metabolism · 2025 · 12 citations · 41 references

Concepts

MedicineNutritional SciencesBone MetabolismInflammationSignal TransductionBone FormationBone Metabolism DisordersMetabolic Bone DiseaseOsteoclast BiologyOsteoclast FunctionOsteogenesisMembrane Protein PalmitoylationOsteoclast MetabolismOsteoclast RegulationOsteolytic Bone DiseaseOsteolytic Bone Lesions

References

41

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love, Wolfgang Huber, Simon Anders · Genome biology · 2014 · 100.5K citations · Full text

Life Sciences, Bioinformatics, Biostatistics +15

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Aravind Subramanian, Pablo Tamayo, Vamsi K. Mootha et al. · Proceedings of the National Academy of Sciences · 2005 · 56.7K citations · Full text

Life Sciences, Bioinformatics, Oncology +12

fastp: an ultra-fast all-in-one FASTQ preprocessor

Shifu Chen, Yanqing Zhou, Yaru Chen et al. · Bioinformatics · 2018 · 29.7K citations · Full text

Computing, Computer Engineering, Computer Science +8

HISAT: a fast spliced aligner with low memory requirements

Daehwan Kim, Ben Langmead, Steven L. Salzberg · Nature Methods · 2015 · 26.1K citations · Full text

Engineering, Computer Engineering, Computer Science +3

HTSeq—a Python framework to work with high-throughput sequencing data

Simon Anders, Paul Theodor Pyl, Wolfgang Huber · Bioinformatics · 2014 · 22.7K citations · Full text

Life Sciences, Bioinformatics, Biology +11