Theranostics · 2025 · 13 citations · 0 references
MedicineCell BiologyOncologyMolecular OncologyOncogenesSignal TransductionAutophagy In CancerCancer Cell SignalingChemotherapy ResistanceGlioblastomaMitophagyOncogenic Signaling PathwaysBnip3-mediated MitophagyGlioblastoma Molecular PathwaysGlioblastoma Therapeutic ResistanceGlioblastoma Tumor BiologyMitophagy SignalingMolecular Drug ResistanceTherapeutic Target IdentificationTumor Resistance
Our findings indicate that CANX functions as an oncogene in GBM. We also characterize the CANX/MEK/ERK/BNIP3 mitophagy pathway, provide new insights into the molecular mechanism of GBM drug resistance, and identify a therapeutic target.