Concepedia

A single point mutation (Phe340-->Leu340) of a conserved phenylalanine abolishes 4-[125I]iodo-(2,5-dimethoxy)phenylisopropylamine and [3H]mesulergine but not [3H]ketanserin binding to 5-hydroxytryptamine2 receptors.

M S Choudhary, S Craigo, Bryan L. Roth

Molecular Pharmacology · 1993 · 41 citations · 0 references

Concepts

MedicineMolecular BiologyPharmacologyMolecular NeuroscienceMolecular PharmacologyNeuropharmacologyLigand BindingNeurotransmitter ReceptorsReceptor PharmacologySerotonergic Pharmacology5-Hydroxytryptamine Receptor PharmacologyD2-like Dopamine ReceptorsDopamine Receptor SubtypesPoint Mutation AnalysisPoint Mutation Effects