Quantitative Imaging in Live Human Cells Reveals Intracellular α1-Adrenoceptor Ligand-Binding Sites

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype.

Debra A. Schwinn, Jon W. Lomasney, W Lorenz et al. · Journal of Biological Chemistry · 1990 · 418 citations · Full text

Medicine, Pharmacology, Cell Signaling +13

Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter

Dirk Gründemann, Birgit Schechinger, Gudrun Rappold et al. · Nature Neuroscience · 1998 · 372 citations · Full text

Life Sciences, Neurobiology, Neuroscience +14

RS-17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-alpha, alpha-dimethyl-1H-indole-3-ethanamine hydrochloride), a selective alpha 1A-adrenoceptor antagonist, displays low affinity for functional alpha 1-adrenoceptors in human prostate: implications for adrenoceptor classification.

Anthony Ford, Nicolas F. Arredondo, David R. Blue et al. · Molecular Pharmacology · 1996 · 193 citations

Medicine, Pharmacology, Urology +13

Noradrenaline contractions of human prostate mediated by α_1c‐(α_1c‐) adrenoceptor subtype

Ian Marshall, Richard P. Burt, C.R. Chappie · British Journal of Pharmacology · 1995 · 155 citations · Full text

Medicine, Pharmacology, Hormone Biochemistry +9