Chitosan-modified polymeric nanoparticles for the nose-to-brain drug delivery of paroxetine: an <i>in vitro</i> and <i>in vivo</i> evaluation

Abstract

Chitosan-modified PLGA nanoparticles can increase the therapeutic potential of the paroxetine drug by increasing the targeted delivery through a cellular uptake mechanism. The mucoadhesive polymers enhance drug delivery via the intranasal route.