Investigation of cefiderocol resistance prevalence and resistance mechanisms in carbapenem-resistant <i>Pseudomonas aeruginosa</i>, Germany 2019–21

Abstract

Our findings show the low prevalence of cefiderocol resistance among CR-Pa isolates, showing its potential as an effective treatment option. However, the complex genetic landscape of resistance mechanisms, particularly mutations affecting iron transport and other TonB-dependent receptors, requires continuous monitoring and functional analyses to identify and manage potential resistance mechanisms. This study provides a foundation for future research to improve antimicrobial resistance prediction and develop targeted therapies against CR-Pa.