Acta Pharmaceutica Sinica B · 2024 · 11 citations · 30 references
Life SciencesImmunologyOncologyCancer ImmunologyImmunotherapyTumor ImmunologyAntitumor T Cell ResponsesCancer ImmunotherapyCheckpoint Inhibitor TherapyImmune Checkpoint InhibitorsImmune Checkpoint RegulationImmune CheckpointsAdaptive Antitumor ImmunityCheckpoint Modulation In CancerImmunosuppressive CompoundsImmunosuppressive FunctionPd-l1 BlockadeProgrammed Cell Death Protein 1 (Pd-1) PathwayT Cell Checkpoint InhibitionT-cell Mediated Immunity
T-cell-mediated antitumor immunity. Notably, combining the PRMT5 methyltransferase inhibitor GSK591 with PD-L1 blockade efficiently inhibited liver cancer growth and improved overall survival in mice. Collectively, our findings reveal the immunosuppressive role and mechanism of PRMT5 in liver cancer and highlight that targeting PRMT5 could boost checkpoint immunotherapy efficacy.
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Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3
Jun Wang, Miguel F. Sanmamed, Ila Datar et al. · Cell · 2018 · 883 citations
Induction and transcriptional regulation of the co-inhibitory gene module in T cells
Norio Chihara, Asaf Madi, Takaaki Kondo et al. · Nature · 2018 · 457 citations · Full text