Journal of the American Heart Association · 2024 · 32 citations · 35 references
Our study highlights the key role of Piezo1 in atherosclerotic endothelial inflammation, proposing the Piezo1-Ca<sup>2+</sup>/CaM/CaMKII-FAK/Src-YAP axis as a previously unknown endothelial mechanotransduction pathway. Piezo1 is expected to become a potential therapeutic target for atherosclerosis and cardiovascular diseases.
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Heart Disease and Stroke Statistics—2021 Update
Salim S. Virani, Álvaro Alonso, Hugo J. Aparicio et al. · Circulation · 2021 · 5.5K citations · Full text
Hemodynamic Shear Stress and Its Role in Atherosclerosis
Adel M. Malek · JAMA · 1999 · 3.5K citations
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
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Fernando Calvo, Nil Ege, A. Grande-García et al. · Nature Cell Biology · 2013 · 1.4K citations · Full text
Mechanobiology, Engineering, Cancer-associated Fibroblasts +10
Piezo1 integration of vascular architecture with physiological force
Jing Li, Bing Hou, Sarka Tumova et al. · Nature · 2014 · 1.2K citations · Full text