HDAC7 drives glioblastoma to a mesenchymal-like state via LGALS3-mediated crosstalk between cancer cells and macrophages

Shulin Zhao, Rongrong Zhao, Chuanzheng Wang, Caizhi Ma, Zijie Gao, Boyan Li, Yanhua Qi, Wei Qiu, Ziwen Pan, Shaobo Wang,

Theranostics · 2024 · 22 citations · 30 references

DOIFull text

Open access

Concepts

Abstract

Our findings revealed the role of the novel HDAC7-H3K27ac-SOX8/JUN-LGALS3-ITGB1 axis in maintaining the crosstalk between MES GBM and M2 MDM, highlighting that HDAC7 and LGALS3 may serve as potential prognostic biomarkers and therapeutic targets in GBM.

References

30