Concepedia

ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation

Frederik Link, Yujia Li, Jieling Zhao, Stefan Munker, Weiguo Fan, Zeribe C. Nwosu, Yao Ye, Shanshan Wang

Gut · 2024 · 34 citations · 34 references

DOIFull text

Open access

Abstract

Our findings underscore the hepatoprotective effect of ECM1, which interferes with mediators of LTGF-β1 activation, suggesting ECM1 or its representative peptide as potential antifibrotic therapies in CLD.

References

34

Accurate structure prediction of biomolecular interactions with AlphaFold 3

Josh Abramson, Jonas Adler, Jack Dunger et al. · Nature · 2024 · 10.8K citations · Full text

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

Qin Yu, Ivan Stamenkovic · Genes & Development · 2000 · 1.7K citations · Full text

, , +20

Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

Pierre-jean Wipff, Daniel B. Rifkin, Jean-Jacques Meister et al. · The Journal of Cell Biology · 2007 · 1.3K citations · Full text

, , +15

Fibrosis stage but not NASH predicts mortality and time to development of severe liver disease in biopsy-proven NAFLD

Hannes Hagström, Patrik Nasr, Mattias Ekstedt et al. · Journal of Hepatology · 2017 · 1K citations

, , +14

Latent TGF-β structure and activation

Minlong Shi, Jianghai Zhu, Rui Wang et al. · Nature · 2011 · 975 citations · Full text

, , +3