Inhibition of the NLRP3/caspase-1 cascade related pyroptosis relieved propofol-induced neuroinflammation and cognitive impairment in developing rats

Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits

Vesna Jevtović‐Todorović, Richard E. Hartman, Yukitoshi Izumi et al. · Journal of Neuroscience · 2003 · 2K citations · Full text

Medicine, Anesthesiology, Neuroscience +17

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

Rebecca C. Coll, James R. Hill, Christopher J. Day et al. · Nature Chemical Biology · 2019 · 996 citations · Full text

Life Sciences, Immunology, Molecular Biology +13

(S)-1-((S)-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2 R,3 S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1β and IL-18

Woods Wannamaker, Robert M. D. Davies, Mark Namchuk et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 319 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

Joseph Flores, Anastasia Noël, Bénédicte Foveau et al. · Nature Communications · 2018 · 286 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Developmental Stage-dependent Persistent Impact of Propofol Anesthesia on Dendritic Spines in the Rat Medial Prefrontal Cortex

Adrian Briner, Irina Nikonenko, Mathias De Roo et al. · Anesthesiology · 2011 · 245 citations · Full text

Medicine, Neurobiology, Neuroscience +17