International Journal of Biological Sciences · 2024 · 20 citations · 0 references
MedicineMolecular BiologyOncologyMetastasisMolecular OncologyTumor ProgressionCancer Cell SignalingMetastatic Disease TreatmentMetastatic Signaling PathwaysOncogenic Signaling PathwaysProstate CancerSignal Transduction In CancerBeta-catenin RegulationCancer Metastasis MechanismsCancer Signaling PathwaysCanonical Beta-catenin SignalingMetastasis Of Prostate CancerMetastatic MechanismsMetastatic SignalingTumor Suppressor Pathways
The NDR1/FBXO11 axis outlines a non-canonical β-catenin degradation pathway crucial in regulating EMT and prostate cancer cell metastasis. NDR1 activation, particularly with aNDR1, could offer a promising therapeutic avenue against prostate cancer metastasis.