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Detection of cefiderocol and aztreonam/avibactam resistance in epidemic <i>Escherichia coli</i> ST-361 carrying <i>bla</i> <sub>NDM-5</sub> and <i>bla</i> <sub>KPC-3</sub> from foreign fighters evacuated from Ukraine

DOIFull Paper Access

11

Citations

9

References

2024

Year

Melissa J. Martin, Ting L. Luo, Valentyn Kovalchuk, Viacheslav Kondratiuk, Henry D. Dao, Iryna Kovalenko, Brandon J. Plaza, Joanna M. Kettlewell, Cole Anderson, Jason R. Smedberg,
Antimicrobial Agents and Chemotherapy

Abstract

Genomic surveillance detected clonal <i>Escherichia coli</i> sequence type-361 isolates carrying <i>bla</i><sub>NDM-5</sub>, <i>bla</i><sub>KPC-3</sub>, <i>bla</i><sub>CTX-M-15</sub>, and <i>rmtB1</i> from a patient in Ukraine and four wounded foreign soldiers evacuated to Germany. Isolates were non-susceptible to carbapenems, aminoglycosides, and cefiderocol and aztreonam/avibactam due to a PBP3 YRIN insertion and the <i>bla</i><sub>CMY-145</sub> AmpC β-lactamase. Coordinated surveillance efforts across civilian, military, and veteran healthcare systems are essential to prevent further spread as international volunteers return home after medical evacuation from Ukraine.

References

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