Progressive Development of Cefiderocol Resistance in <i>Escherichia coli</i> During Therapy is Associated With an Increase in <i>bla</i>NDM-5 Copy Number and Gene Expression

Abstract

The findings in our patient suggest that increased copy numbers of blaNDM genes through translocation events are used by Enterobacterales to evade cefiderocol-mediated cell death. The frequency of increased blaNDM-5 expression in contributing to cefiderocol resistance needs investigation.