Asymmetric synthesis of acyclic N–N axially chiral indole compounds <i>via</i> catalytic <i>N</i>-acylation reaction

Abstract

Herein, we present an enantioselective synthesis of N -aminoindoles bearing a N–N axis via chiral isothiourea catalyzed asymmetric N -acylation. Notably, some of the products exhibited promising cytotoxicity activities against some cancer cell lines.