Hepatic miR-363 promotes nonalcoholic fatty liver disease by suppressing INSIG1

Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma

Jin Hou, Li Lin, Weiping Zhou et al. · Cancer Cell · 2011 · 692 citations · Full text

Medicine, Molecular Biology, Oncology +17

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

Rui E. Castro, Duarte M. S. Ferreira, Marta B. Afonso et al. · Journal of Hepatology · 2012 · 348 citations

Life Sciences, Biochemistry, Molecular Biology +17

Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer

Giridhar Mudduluru, Jonahunnatha Nesson George-William, Santoshi Muppala et al. · Bioscience Reports · 2010 · 331 citations · Full text

Medicine, Molecular Biology, Oncology +16

Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis

Luke J. Engelking, Hiroshi Kuriyama, Robert E. Hammer et al. · Journal of Clinical Investigation · 2004 · 265 citations · Full text

Life Sciences, Biochemistry, Endocrinology +15

Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake

Yi Gong, Joon No Lee, Peter Chang-Whan Lee et al. · Cell Metabolism · 2006 · 260 citations · Full text

Life Sciences, Biochemistry, Cell Biology +14