Concepedia

RNA Helicase DDX5 Maintains Cardiac Function by Regulating <i>CamkIIδ</i> Alternative Splicing

Kangni Jia, Haomai Cheng, Wenqi Ma, Lingfang Zhuang, Hao Li, Zhigang Li, Ziyang Wang, Hang Sun, Yuke Cui, Hang Zhang,

Circulation · 2024 · 16 citations · 32 references

DOI

Abstract

These findings reveal a role for DDX5 in maintaining calcium homeostasis and cardiac function by regulating alternative splicing in cardiomyocytes, identifying the DDX5 as a potential target for therapeutic intervention in HF.

References

32

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Connie W. Tsao, Aaron W. Aday, Zaid Almarzooq et al. · Circulation · 2022 · 5.8K citations · Full text

rMATS: Robust and flexible detection of differential alternative splicing from replicate RNA-Seq data

Shihao Shen, Juw Won Park, Zhixiang Lu et al. · Proceedings of the National Academy of Sciences · 2014 · 2.7K citations · Full text

AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors

Hui Hu, Ya-Ru Miao, Long-Hao Jia et al. · Nucleic Acids Research · 2018 · 926 citations · Full text

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RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing

Wei Guo, Sebastian Schäfer, Marion L. Greaser et al. · Nature Medicine · 2012 · 586 citations · Full text

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Deep RNA Sequencing Reveals Dynamic Regulation of Myocardial Noncoding RNAs in Failing Human Heart and Remodeling With Mechanical Circulatory Support

Kai‐Chien Yang, Kathryn A. Yamada, Akshar Patel et al. · Circulation · 2014 · 453 citations · Full text