Concepedia

3-Methyladenine attenuates neuroinflammation and improves cognitive function in sepsis-associated encephalopathy by inhibiting autophagy

Tao Zhu, Yinping Yao, Junchao Ding, Chengyue Zhang, Ningxiao Xia, Yilin Tao, Wenhao Zhang, Hantao Qi, Lifen Gong, Peifang Jiang

International Immunopharmacology · 2024 · 12 citations · 52 references

DOI

Concepts

References

52

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou, Amir S. Yazdi, Philippe Menu et al. · Nature · 2010 · 5.4K citations

, , +12

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

Theodore J. Iwashyna, E. Wesley Ely, Dylan M. Smith et al. · JAMA · 2010 · 2.6K citations

, , +16

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

Chong-Shan Shi, Kevin Shenderov, Ning-Na Huang et al. · Nature Immunology · 2012 · 1.4K citations · Full text

, , +16

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

Youtong Wu, Huiling Tan, Guanghou Shui et al. · Journal of Biological Chemistry · 2010 · 1.1K citations · Full text

, , +15

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

James Harris, Michelle Hartman, Caitrionna Roche et al. · Journal of Biological Chemistry · 2011 · 785 citations · Full text

, , +17