Endogenous glucocorticoids are required for normal macrophage activation and gastric <i>Helicobacter pylori</i> immunity

Abstract

Signaling by endogenous glucocorticoids primes macrophages toward more robust responses to pathogens. Disruption of glucocorticoid signaling caused dysregulation of the chromatin landscape, blunted proinflammatory gene activation upon bacterial challenge, and impaired the gastric inflammatory response to Helicobacter pylori infection.